Endocrine Abstracts

Objective: Previously, we identified that knockdown of calcium/calmodulin-dependent serine protein kinase (Cask) in β cells in vitro resulted in decreased insulin secretion. We then used the Cre-loxP system to specifically delete the Cask gene in β cells of mice, and the mice exhibited impaired glucose tolerance and glucose-stimulated insulin secretion under a normal chow diet. However, under a high-fat diet (HFD), the insulin sensitivity a...